Receptor Dependence by Mucosal Effector B Cutting Edge: Dichotomy of Homing

Cutting Edge Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns

Tissue-specific homing of effector and memory T cells to skin and small intestine requires the imprinting of specific combinations of adhesion molecules and chemokine receptors by dendritic cells in the draining lymph nodes. In this study, we demonstrate that CD8 T cells activated by Ag-pulsed bone marrow-derived dendritic cells were induced to express the small intestine homing receptors 4 7 i...

Precedes Effector Th Cell Development Cutting Edge: Induction of Follicular Homing

Cutting edge: instructive role of peripheral tissue cells in the imprinting of T cell homing receptor patterns.

Tissue-specific homing of effector and memory T cells to skin and small intestine requires the imprinting of specific combinations of adhesion molecules and chemokine receptors by dendritic cells in the draining lymph nodes. In this study, we demonstrate that CD8(+) T cells activated by Ag-pulsed bone marrow-derived dendritic cells were induced to express the small intestine homing receptors al...

Cutting edge: expression of chemokine receptor CXCR1 on human effector CD8+ T cells.

IL-8 is a potent inflammatory cytokine that induces chemotaxis of neutrophils expressing CXCR1 and CXCR2, thus indicating its involvement in the migration of these cells to inflammatory sites where bacteria proliferate. Presently, we showed that CXCR1(+) cells were predominantly found among CD8(+) T cells having effector phenotype, and that the expression of CXCR1 was positively correlated with...

Adhesion Molecules Associated with Female Genital Tract Infection

Efforts to develop vaccines that can elicit mucosal immune responses in the female genital tract against sexually transmitted infections have been hampered by an inability to measure immune responses in these tissues. The differential expression of adhesion molecules is known to confer site-dependent homing of circulating effector T cells to mucosal tissues. Specific homing molecules have been ...